A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.

Several mycobacterial antigens, identified by monoclonal antibodies and patient sera, have been found to be homologous to stress or heat-shock proteins (hsp) defined in Escherichia coli and yeast. A major antigen recognized by most Mycobacterium leprae-reactive human T cell lines and cell wall-reactive T cell clones is a 10-kD protein that has now been cloned and sequenced. The predicted amino acid sequence of this protein is 44% homologous to the hsp 10 (GroES) of E. coli. The purified native and recombinant 10-kD protein was found to be a stronger stimulator of peripheral blood T cell proliferation than other native and recombinant M. leprae proteins tested. The degree of reactivity paralleled the response to intact M. leprae throughout the spectrum of leprosy. Limiting-dilution analysis of peripheral blood lymphocytes from a patient contact and a tuberculoid patient indicated that approximately one third of M. leprae-reactive T cell precursors responded to the 10-kD antigen. T cell lines derived from lepromin skin tests were strongly responsive to the 10-kD protein. T cell clones reactive to both the purified native and recombinant 10-kD antigens recognized M. leprae-specific epitopes as well as epitopes crossreactive with the cognate antigen of M. tuberculosis. Further, the purified hsp 10 elicited strong delayed-type hypersensitivity reactions in guinea pigs sensitized to M. leprae. The strong T cell responses against the M. leprae 10-kD protein suggest a role for this heat-shock cognate protein in the protective/resistant responses to infection

Quasi-Particles in Two-Dimensional Hubbard Model: Splitting of Spectral Weight

It is shown that the energy $(\varepsilon)$ and momentum $(k)$ dependences of the electron self-energy function $\Sigma (k, \varepsilon + i0) \equiv \Sigma^{R}(k, \varepsilon)$ are, ${\rm Im} \Sigma^{R} (k, \varepsilon) = -a\varepsilon^{2}|\varepsilon - \xi_{k}|^{- \gamma (k)}$ where $a$ is some constant, $\xi_{k} = \varepsilon(k)-\mu, \varepsilon(k)$ being the band energy, and the critical exponent $\gamma(k)$, which depends on the curvature of the Fermi surface at $k$, satisfies, $0 \leq \gamma(k) \leq 1$. This leads to a new type of electron liquid, which is the Fermi liquid in the limit of $\varepsilon, \xi_{k} \rightarrow 0$ but for $\xi_{k} \neq 0$ has a split one-particle spectra as in the Tomonaga-Luttinger liquid.Comment: 8 pages (LaTeX) 4 figures available upon request will be sent by air mail. KomabaCM-preprint-O

Critical behavior in a cross-situational lexicon learning scenario

The associationist account for early word-learning is based on the co-occurrence between objects and words. Here we examine the performance of a simple associative learning algorithm for acquiring the referents of words in a cross-situational scenario affected by noise produced by out-of-context words. We find a critical value of the noise parameter $\gamma_c$ above which learning is impossible. We use finite-size scaling to show that the sharpness of the transition persists across a region of order $\tau^{-1/2}$ about $\gamma_c$, where $\tau$ is the number of learning trials, as well as to obtain the learning error (scaling function) in the critical region. In addition, we show that the distribution of durations of periods when the learning error is zero is a power law with exponent -3/2 at the critical point

Observation of contemporaneous optical radiation from a gamma-ray burst

The origin of gamma-ray bursts (GRBs) has been enigmatic since their discovery. The situation improved dramatically in 1997, when the rapid availability of precise coordinates for the bursts allowed the detection of faint optical and radio afterglows - optical spectra thus obtained have demonstrated conclusively that the bursts occur at cosmological distances. But, despite efforts by several groups, optical detection has not hitherto been achieved during the brief duration of a burst. Here we report the detection of bright optical emission from GRB990123 while the burst was still in progress. Our observations begin 22 seconds after the onset of the burst and show an increase in brightness by a factor of 14 during the first 25 seconds; the brightness then declines by a factor of 100, at which point (700 seconds after the burst onset) it falls below our detection threshold. The redshift of this burst, approximately 1.6, implies a peak optical luminosity of 5 times 10^{49} erg per second. Optical emission from gamma-ray bursts has been generally thought to take place at the shock fronts generated by interaction of the primary energy source with the surrounding medium, where the gamma-rays might also be produced. The lack of a significant change in the gamma-ray light curve when the optical emission develops suggests that the gamma-rays are not produced at the shock front, but closer to the site of the original explosion.Comment: 10 pages, 2 figures. Accepted for publication in Nature. For additional information see http://www.umich.edu/~rotse

Implications of the γ\gamma-ray Polarization of GRB 021206

We compare two possible scenarios for the producing of high level of polarization within the prompt emission of a GRB: synchrotron emission from a relativistic jet with a uniform (in space and time) magnetic field and synchrotron emission from a jet with a random magnetic field in the plane of the shock. Somewhat surprisingly we find that both scenarios can produce a comparable level of polarization ($\sim 45-50$% for the uniform field and $\sim 30-35$% for a random field). Uniform time independent field most naturally arises by expansion of the field from the compact object. It requires a $10^{12}$G field at the source and a transport of the field as $\propto R^{-1}$. It {\it does not} imply Poynting flux domination of the energy of the wind. There is a serious difficulty however, within this scenario, accounting for particle acceleration (which requires random magnetic fields) both for Poynting flux and non-Poynting flux domination. Significant polarization can also arise from a random field provided that the observer is located within $1/\Gamma$ orientation from a narrow ($\theta_j \sim 1/\Gamma$) jet. While most jets are wider, the jet of GRB 021206 from which strong polarization was recently observed, was most likely very narrow. GRB 021206 is among the strongest bursts ever. Adopting the energy-angle relation we find an estimated angle of $<1/40$rad or even smaller. Thus, for this particular burst the required geometry is not unusual. We conclude that the RHESSI observations suggest that the prompt emission results from synchrotron radiation. However, in view of the comparable levels of polarizations predicted by both the random field and the homogeneous field scenarios these observations are insufficient to rule out or confirm either one.Comment: 14 pages, 4 figure

The Discovery and Broad-band Follow-up of the Transient Afterglow of GRB 980703

We report on the discovery of the radio, infrared and optical transient coincident with an X-ray transient proposed to be the afterglow of GRB 980703. At later times when the transient has faded below detection, we see an underlying galaxy with R=22.6; this galaxy is the brightest host galaxy (by nearly 2 magnitudes) of any cosmological GRB thus far. In keeping with an established trend, the GRB is not significantly offset from the host galaxy. Interpreting the multi-wavelength data in the framework of the popular fireball model requires that the synchrotron cooling break was between the optical and X-ray bands on July 8.5 UT and that the intrinsic extinction of the transient is Av=0.9. This is somewhat higher than the extinction for the galaxy as a whole, as estimated from spectroscopy.Comment: 5 pages, 3 figures, and 2 tables. Submitted to the Astrophysical Journal Letters on 27 August 199

Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.

Crohn's disease is a chronic inflammatory condition largely affecting the terminal ileum and large bowel. A contributing cause is the failure of an adequate acute inflammatory response as a result of impaired secretion of pro-inflammatory cytokines by macrophages. This defective secretion arises from aberrant vesicle trafficking, misdirecting the cytokines to lysosomal degradation. Aberrant intestinal permeability is also well-established in Crohn's disease. Both the disordered vesicle trafficking and increased bowel permeability could result from abnormal lipid composition. We thus measured the sphingo- and phospholipid composition of macrophages, using mass spectrometry and stable isotope labelling approaches. Stimulation of macrophages with heat-killed Escherichia coli resulted in three main changes; a significant reduction in the amount of individual ceramide species, an altered composition of phosphatidylcholine, and an increased rate of phosphatidylcholine synthesis in macrophages. These changes were observed in macrophages from both healthy control individuals and patients with Crohn's disease. The only difference detected between control and Crohn's disease macrophages was a reduced proportion of newly-synthesised phosphatidylinositol 16:0/18:1 over a defined time period. Shotgun lipidomics analysis of macroscopically non-inflamed ileal biopsies showed a significant decrease in this same lipid species with overall preservation of sphingolipid, phospholipid and cholesterol composition

Local dark matter searches with LISA

The drag-free satellites of LISA will maintain the test masses in geodesic motion over many years with residual accelerations at unprecedented small levels and time delay interferometry (TDI) will keep track of their differential positions at level of picometers. This may allow investigations of fine details of the gravitational field in the Solar System previously inaccessible. In this spirit, we present the concept of a method to measure directly the gravitational effect of the density of diffuse Local Dark Matter (LDM) with a constellation of a few drag-free satellites, by exploiting how peculiarly it would affect their relative motion. Using as test bed an idealized LISA with rigid arms, we find that the separation in time between the test masses is uniquely perturbed by the LDM, so that they acquire a differential breathing mode. Such a LDM signal is related to the LDM density within the orbits and has characteristic spectral components, with amplitudes increasing in time, at various frequencies of the dynamics of the constellation. This is the relevant result, in that the LDM signal is brought to non-zero frequencies.Comment: 8 pages, 1 figure; v2: minor changes to match the version in press on Classical and Quantum Gravity (special issue for the 7th International LISA Symposium proceedings

SubmilliJansky Transients in Archival Radio Observations

[ABRIDGED] We report the results of a 944-epoch survey for transient sources with archival data from the Very Large Array spanning 22 years with a typical epoch separation of 7 days. Observations were obtained at 5 or 8.4 GHz for a single field of view with a full-width at half-maximum of 8.6' and 5.1', respectively, and achieved a typical point-source detection threshold at the beam center of ~300 microJy per epoch. Ten transient sources were detected with a significance threshold such that only one false positive would be expected. Of these transients, eight were detected in only a single epoch. Two transients were too faint to be detected in individual epochs but were detected in two-month averages. None of the ten transients was detected in longer-term averages or associated with persistent emission in the deep image produced from the combination of all epochs. The cumulative rate for the short timescale radio transients above 370 microJy at 5 and 8.4 GHz is 0.07 < R < 40 deg^-2 yr^-1, where the uncertainty is due to the unknown duration of the transients, 20 min < t_char < 7 days. A two-epoch survey for transients will detect 1.5 +/- 0.4 transient per square degrees above a flux density of 370 microJy. Two transients are associated with galaxies at z=0.040 and z=0.249. These may be similar to the peculiar Type Ib/c radio supernova SN 1998bw associated with GRB 980428. Six transients have no counterparts in the optical or infrared (R=27, Ks=18). The hosts and progenitors of these transients are unknown.Comment: Accepted for ApJ; full quality figures available at http://astro.berkeley.edu/~gbower/ps/rt.pd